The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic α-helix

@article{Hinson2009TheAP,
  title={The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic α-helix},
  author={E. Hinson and P. Cresswell},
  journal={Proceedings of the National Academy of Sciences},
  year={2009},
  volume={106},
  pages={20452 - 20457}
}
  • E. Hinson, P. Cresswell
  • Published 2009
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • Lipid droplets are intracellular lipid-storage organelles that are thought to be derived from the endoplasmic reticulum (ER). Several pathogens, notably hepatitis C virus, use lipid droplets for replication. Numerous questions remain about how lipid droplets are generated and used by viruses. Here we show that the IFN-induced antiviral protein viperin, which localizes to the cytosolic face of the ER and inhibits HCV, localizes to lipid droplets. We show that the N-terminal amphipathic α-helix… CONTINUE READING
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