The antiviral innate immune response in fish: evolution and conservation of the IFN system.

@article{Langevin2013TheAI,
  title={The antiviral innate immune response in fish: evolution and conservation of the IFN system.},
  author={Christelle Langevin and Elina Aleksejeva and Gabriella Passoni and Nuno R. Palha and J. -P. Levraud and Pierre Boudinot},
  journal={Journal of molecular biology},
  year={2013},
  volume={425 24},
  pages={
          4904-20
        }
}
Innate immunity constitutes the first line of the host defense after pathogen invasion. Viruses trigger the expression of interferons (IFNs). These master antiviral cytokines induce in turn a large number of interferon-stimulated genes, which possess diverse effector and regulatory functions. The IFN system is conserved in all tetrapods as well as in fishes, but not in tunicates or in the lancelet, suggesting that it originated in early vertebrates. Viral diseases are an important concern of… CONTINUE READING
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