The antiviral immune response in mice devoid of immunoproteasome activity.

@article{Basler2011TheAI,
  title={The antiviral immune response in mice devoid of immunoproteasome activity.},
  author={Michael Basler and Ulrike Beck and Christopher J. Kirk and Marcus Groettrup},
  journal={Journal of immunology},
  year={2011},
  volume={187 11},
  pages={5548-57}
}
The replacement of the catalytically active proteasome subunits β1, β2, and β5 by the immunoproteasome subunits low molecular mass polypeptide (LMP) 2 (β1i), multicatalytic endopeptidase complex-like-1 (MECL-1) (β2i), and LMP7 (β5i) is required for the production of numerous class I ligands. Hitherto, investigation of the immunoproteasome was confined to the analysis of mice deficient for one or two immunosubunits. In this study, we characterized LMP2(-/-)/MECL-1(-/-) double-deficient mice and… CONTINUE READING