The antiviral activities of artemisinin and artesunate.

  title={The antiviral activities of artemisinin and artesunate.},
  author={Thomas Efferth and Marta R Romero and Dana G. Wolf and Thomas Stamminger and Jose J. G. Marin and Manfred Marschall},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  volume={47 6},
  • T. Efferth, M. Romero, M. Marschall
  • Published 15 September 2008
  • Biology, Chemistry, Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Traditional Chinese medicine commands a unique position among all traditional medicines because of its 5000 years of history. Our own interest in natural products from traditional Chinese medicine was triggered in the 1990s, by artemisinin-type sesquiterpene lactones from Artemisia annua L. As demonstrated in recent years, this class of compounds has activity against malaria, cancer cells, and schistosomiasis. Interestingly, the bioactivity of artemisinin and its semisynthetic derivative… 

Figures and Tables from this paper

Antiviral and Immunomodulation Effects of Artemisia

Artemisinin’s importance in indigenous medicinal systems and drug discovery systems holds great potential for further investigation into its biological activities, especially its role in viral infection and inflammation.

Biological Activities of Artemisinins Beyond Anti-Malarial: a Review

It is likely that artemisinin-based drugs will become an important armamentarium impeding a number of diseases beyond malaria, as they have shown anti-cancer properties in both cell lines and animal models.

Pharmacological Potentials of Artemisinin and Related Sesquiterpene Lactones: Recent Advances and Trends

This review will centre on the significant achievements in recent years with regard to the chemistry and biological properties of SL from A. annua, with particular attention on artemisinin and related compounds.

Artemisinin–second career as anticancer drug?

Larger scale of Phase II and III clinical studies are required now to further develop artemisinin-type compounds as novel anticancer drugs.

Enhancing artemisinin content in and delivery from Artemisia annua: a review of alternative, classical, and transgenic approaches

This review analyses the most recent scientific research conducted for the purpose of enhancing artemisinin production and discusses these artemisInin enhancement strategies, understand mechanisms modulating its biosynthesis, and evaluate if roots play any role in artemis inin production.

Anti-malarial drug: the emerging role of artemisinin and its derivatives in liver disease treatment

This review provides a comprehensive discussion of the underlying molecular mechanisms and signaling pathways of artemisinin and its derivatives in treating liver diseases and helps to determine whether these drugs may serve as promising medicines for the treatment of liver diseases in the future.

A review on pharmacological properties of Artemisia annua

Traditional uses, phytochemistry and pharmacology of Artemisiasps providing preliminary information and a direction for the basic and clinical research on Artemisia annua are given.


This review aims to highlight the importance of including natural plants and plants derived compounds in this investigation of SARS-CoV-2, and particularly focused on compounds from Artemisia species (artemisinin and its derivatives), as this plant is highly valuable and has various pharmacological profiles.

Novel Developments on Artemisinin and Its Derivatives for Cancer Therapy

Novel developments on Artemisinin and its derivatives concerning mode of action, metabolism, toxicity, in vivo effects, clinical application and biotechnological production methods are summarized.



Willmar Schwabe Award 2006: antiplasmodial and antitumor activity of artemisinin--from bench to bedside.

It is found that the active principle of Artemisia annua L., artemisinin, exerts not only antimalarial activity but also profound cytotoxicity against tumor cells, indicating that artesunate is not involved in multidrug resistance.

Structure-activity relationships of the antimalarial agent artemisinin. 6. The development of predictive in vitro potency models using CoMFA and HQSAR methodologies.

CoMFA and HQSAR models were developed having statistically excellent properties, which also possessed good predictive ability for test set compounds and did an outstanding job in statistical analysis and also handled predictions well.

The anti-malarial artesunate is also active against cancer.

A comparison of ART's cytotoxicity with those of other standard cytostatic drugs showed that ART was active in molar ranges comparable to those of established anti-tumor drugs, clues that ART may be a promising novel candidate for cancer chemotherapy.

Antiviral effect of artemisinin from Artemisia annua against a model member of the Flaviviridae family, the bovine viral diarrhoea virus (BVDV).

A potential usefulness of artemisinin in combination with current pharmacological therapy for the treatment of human and veterinary infections by flaviviruses is suggested.

Artemisinins for schistosomiasis and beyond.

The effect of artemisinin-based combination therapy on young children co-infected with Plasmodium sp and Schistosoma haematobium is described, and the promising activity of art Artemisinins against intestinal and liver flukes in vivo, as well as against cancer cells is reviewed.

Artemisinin: mechanisms of action, resistance and toxicity.

  • S. Meshnick
  • Chemistry, Medicine
    International journal for parasitology
  • 2002

Mechanisms of Action of Ribavirin in Antiviral Therapies

The mode of ribavirin's direct antiviral activities can be ascribed to several possible mechanisms, including the recently described activity as an RNA mutagen, a property that may be important in driving a rapidly mutating RNA virus over the threshold to ‘error catastrophe′.

The anti-malaria drug artesunate inhibits replication of cytomegalovirus in vitro and in vivo.

Artemisinin‐based combination therapies for uncomplicated malaria

The goal of potent, safe, easy‐to‐administer and inexpensive ACTs may see trioxolanes in place of artemisinin derivatives, as well as novel partner drugs such as pyronaridine or naphthoquine, in the future.