The antitumour activity of alkylating agents is not correlated with the levels of glutathione, glutathione transferase and O6-alkylguanine-DNA-alkyltransferase of human tumour xenografts. EORTC SPG and PAMM Groups.

Abstract

Twenty-three human xenografts, including five colon, five gastric, nine lung (three small cell lung cancer) and four breast carcinomas, were investigated for their sensitivity to nitrosoureas, dacarbazine (DTIC), cyclophosphamide (CTX) and cisplatin (DDP). In 12 cases, at least one of the drugs produced complete or partial remission, in 2, a minor… (More)

Topics

Cite this paper

@article{DIncalci1998TheAA, title={The antitumour activity of alkylating agents is not correlated with the levels of glutathione, glutathione transferase and O6-alkylguanine-DNA-alkyltransferase of human tumour xenografts. EORTC SPG and PAMM Groups.}, author={Maurizio D'Incalci and Miriam Bonfanti and Antonio Pifferi and E. Mascellani and Giovanna Tagliabue and Dietmar P. Berger and H. H. Fiebig}, journal={European journal of cancer}, year={1998}, volume={34 11}, pages={1749-55} }