The antitumoral, trypanocidal and antileishmanial activities of extract and alkaloids isolated from Duguetia furfuracea.

  title={The antitumoral, trypanocidal and antileishmanial activities of extract and alkaloids isolated from Duguetia furfuracea.},
  author={D. B. da Silva and E. C. O. Tulli and G. C. G. Milit{\~a}o and L. Costa-Lotufo and C. Pessoa and M. O. de Moraes and S. Albuquerque and J. D. de Siqueira},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  volume={16 11},
  • D. B. da Silva, E. C. O. Tulli, +5 authors J. D. de Siqueira
  • Published 2009
  • Chemistry, Medicine
  • Phytomedicine : international journal of phytotherapy and phytopharmacology
  • The alkaloid extract and five alkaloids isolated from subterranean stem bark of Duguetia furfuracea (Annonaceae) were investigated for the following activities: antitumoral, trypanocidal and leishmanicidal. Dicentrinone showed weak cytotoxicity, but it had the strongest leishmanicidal activity (IC(50) 0.01 microM). Duguetine and duguetine beta-N-oxide caused considerable antitumoral activity in every cell lines evaluated, although duguetine was more active against trypomastigote forms (IC(50) 9… CONTINUE READING
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