The antitumor triazoloacridone C-1305 is a topoisomerase II poison with unusual properties.

@article{Lemke2004TheAT,
  title={The antitumor triazoloacridone C-1305 is a topoisomerase II poison with unusual properties.},
  author={Krzysztof Lemke and Virginie Poindessous and Andrzej Skladanowski and Annette Kragh Larsen},
  journal={Molecular pharmacology},
  year={2004},
  volume={66 4},
  pages={1035-42}
}
C-1305 [S-[[3-(dimethylamino)propyl]amino]-8-hydroxy-6H-v-triazolo[4,5,1-de]acridin-6-one] is a triazoloacridone with excellent activity in colon cancer models. The mechanism of C-1305 is unknown, although similarities in the chemical structure between C-1305 and amsacrine suggest common cellular targets. Here, we report that C-1305 is a topoisomerase II poison that is able to induce cleavable complexes with topoisomerase II in vitro as well as in living cells. Even at optimal concentrations, C… CONTINUE READING

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Interactions of antitumor triazoloacridinones with DNA.

Acta biochimica Polonica • 2007
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