The antitumor triazoloacridone C-1305 is a topoisomerase II poison with unusual properties.

  title={The antitumor triazoloacridone C-1305 is a topoisomerase II poison with unusual properties.},
  author={Krzysztof Lemke and Virginie Poindessous and Andrzej Skladanowski and Annette Kragh Larsen},
  journal={Molecular pharmacology},
  volume={66 4},
C-1305 [S-[[3-(dimethylamino)propyl]amino]-8-hydroxy-6H-v-triazolo[4,5,1-de]acridin-6-one] is a triazoloacridone with excellent activity in colon cancer models. The mechanism of C-1305 is unknown, although similarities in the chemical structure between C-1305 and amsacrine suggest common cellular targets. Here, we report that C-1305 is a topoisomerase II poison that is able to induce cleavable complexes with topoisomerase II in vitro as well as in living cells. Even at optimal concentrations, C… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 16 extracted citations

Interactions of antitumor triazoloacridinones with DNA.

Acta biochimica Polonica • 2007
View 4 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 43 references

Induction of unique structural changes in guanine-rich DNA regions by the triazoloacridone C-1305, a topoisomerase II inhibitor with potent activity toward solid tumors

K Lemke, W Laine, C Bailly, AK Larsen, A. Skaldanowski
EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics; • 2004
View 1 Excerpt

Escargueil AE, and Skladanowski A (2003a) Catalytic topoisomerase II inhibitors in cancer therapy

AK Larsen
Pharmacol Ther 99:167–181 • 2003

Marked activity of irofulven toward human carcinoma cells: comparison with cisplatin and ecteinascidin.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2003
View 4 Excerpts

Cellular roles of DNA topoisomerases: a molecular perspective

Nature Reviews Molecular Cell Biology • 2002
View 1 Excerpt

Similar Papers

Loading similar papers…