The antitumor properties of the alpha3(IV)-(185-203) peptide from the NC1 domain of type IV collagen (tumstatin) are conformation-dependent.

@article{Floquet2004TheAP,
  title={The antitumor properties of the alpha3(IV)-(185-203) peptide from the NC1 domain of type IV collagen (tumstatin) are conformation-dependent.},
  author={Nicolas Floquet and S Brassart Pasco and Laurent Ramont and Philippe Derreumaux and Jean Yves Laronze and Jean Marc Nuzillard and François Xavier Maquart and Alain Jean-Paul Alix and Jean Claude Monboisse},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 3},
  pages={2091-100}
}
Tumor progression may be controlled by various fragments derived from noncollagenous 1 (NC1) C-terminal domains of type IV collagen. We demonstrated previously that a peptide sequence from the NC1 domain of the alpha3(IV) collagen chain inhibits the in vitro expression of matrix metalloproteinases in human melanoma cells through RGD-independent binding to… CONTINUE READING