The antitumor properties of a nontoxic, nitric oxide-modified version of saquinavir are independent of Akt.

@article{MaksimoviIvani2009TheAP,
  title={The antitumor properties of a nontoxic, nitric oxide-modified version of saquinavir are independent of Akt.},
  author={Danijela Maksimovi{\'c}-Ivani{\'c} and S Nevenka Mijatovi{\'c} and Djordje M Miljkovi{\'c} and Ljubica M Harhaji-Trajkovic and Gordana S Timotijevi{\'c} and Marija K Moji{\'c} and Darrin R. Dabideen and Kai Fan Cheng and James A McCubrey and Katia Mangano and Yousef Al-Abed and Massimo Libra and Gianni Garotta and Stanislava D. Sto{\vs}i{\'c}-Gruji{\vc}i{\'c} and Ferdinando Nicoletti},
  journal={Molecular cancer therapeutics},
  year={2009},
  volume={8 5},
  pages={
          1169-78
        }
}
Application of the HIV protease inhibitor saquinavir (Saq) to cancer chemotherapy is limited by its numerous side effects. To overcome this toxicity, we modified the original compound by covalently attaching a nitric oxide (NO) group. We compared the efficacy of the parental and NO-modified drugs in vitro and in vivo. The novel compound saquinavir-NO (Saq-NO) significantly reduced the viability of a wide spectrum of human and rodent tumor cell lines at significantly lower concentration than the… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 14 CITATIONS

Therapeutic potential of nitric oxide-modified drugs in colon cancer cells.

  • Molecular pharmacology
  • 2012
VIEW 9 EXCERPTS
CITES RESULTS, BACKGROUND & METHODS
HIGHLY INFLUENCED

Similar Papers

Loading similar papers…