The antiserotonin agent pizotifen does not increase endurance performance in humans

  title={The antiserotonin agent pizotifen does not increase endurance performance in humans},
  author={J. L. Pannier and Jacques J Bouckaert and Romain Adelin Lefebvre},
  journal={European Journal of Applied Physiology and Occupational Physiology},
This study investigated the effect of the serotonin receptor antagonist pizotifen on endurance performance during treadmill exercise in humans. Eight healthy men exercised to exhaustion on a treadmill at an intensity corresponding to 70% of their maximal oxygen uptake ( $$\dot VO_{2\max } $$ ). Pizotifen was administered orally in a 1-mg dose 5 h before the start of exercise. The study was double blind, using a randomized, placebo-controlled crossover design. Oxygen uptake, heart rate, and… CONTINUE READING


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