The antipsychotic potential of l-stepholidine—a naturally occurring dopamine receptor D1 agonist and D2 antagonist

@article{Natesan2008TheAP,
  title={The antipsychotic potential of l-stepholidine—a naturally occurring dopamine receptor D1 agonist and D2 antagonist},
  author={S. Natesan and G. Reckless and K. Barlow and John Odontiadis and J. Nobrega and G. B. Baker and S. George and D. Mamo and S. Kapur},
  journal={Psychopharmacology},
  year={2008},
  volume={199},
  pages={275-289}
}
  • S. Natesan, G. Reckless, +6 authors S. Kapur
  • Published 2008
  • Medicine
  • Psychopharmacology
  • Rationalel-Stepholidine, a dopamine D2 antagonist with D1 agonist activity, should in theory control psychosis and treat cognitive symptoms by enhancing cortical dopamine transmission. Though several articles describe its impact on the dopamine system, it has not been systematically evaluated and compared to available antipsychotics.Materials and methodsWe examined its in vitro interaction with dopamine D2 and D1 receptors and compared its in vivo pharmacokinetic profile to haloperidol (typical… CONTINUE READING
    49 Citations
    A preclinical assessment of d.l-govadine as a potential antipsychotic and cognitive enhancer.
    • 15
    • Highly Influenced
    • PDF
    (-)-Stepholidine is a potent pan-dopamine receptor antagonist of both G protein- and β-arrestin-mediated signaling
    • 19
    • Highly Influenced
    Dopamine D1 and D3 receptor polypharmacology as a potential treatment approach for substance use disorder
    • 12

    References

    SHOWING 1-10 OF 64 REFERENCES
    (-)-Stepholidine: a potential novel antipsychotic drug with dual D1 receptor agonist and D2 receptor antagonist actions.
    • 80
    • Highly Influential
    Effects of (-)stepholidine in animal models for schizophrenia
    • 28
    • PDF
    Involvement of receptor reserve in D1 agonistic action of (-)-stepholidine in lesioned rats.
    • 23
    Do Novel Antipsychotics Have Similar Pharmacological Characteristics? A Review of the Evidence
    • 662
    • Highly Influential
    • PDF
    Effects of l-Stepholidine on Forebrain Fos Expression: Comparison with Clozapine and Haloperidol
    • 23
    • PDF
    The Neuropsychopharmacology of Phencyclidine: From NMDA Receptor Hypofunction to the Dopamine Hypothesis of Schizophrenia
    • 1,202
    • PDF
    Distribution of D1- and D2-Dopamine Receptors, and Dopamine and Its Metabolites in the Human Brain
    • 367