The antipsychotic potential of l-stepholidine—a naturally occurring dopamine receptor D1 agonist and D2 antagonist

  title={The antipsychotic potential of l-stepholidine—a naturally occurring dopamine receptor D1 agonist and D2 antagonist},
  author={S. Natesan and G. Reckless and K. Barlow and John Odontiadis and J. Nobrega and G. B. Baker and S. George and D. Mamo and S. Kapur},
  • S. Natesan, G. Reckless, +6 authors S. Kapur
  • Published 2008
  • Medicine
  • Psychopharmacology
  • Rationalel-Stepholidine, a dopamine D2 antagonist with D1 agonist activity, should in theory control psychosis and treat cognitive symptoms by enhancing cortical dopamine transmission. Though several articles describe its impact on the dopamine system, it has not been systematically evaluated and compared to available antipsychotics.Materials and methodsWe examined its in vitro interaction with dopamine D2 and D1 receptors and compared its in vivo pharmacokinetic profile to haloperidol (typical… CONTINUE READING
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