The antipsychotic potential of l-stepholidine—a naturally occurring dopamine receptor D1 agonist and D2 antagonist

@article{Natesan2008TheAP,
  title={The antipsychotic potential of l-stepholidine—a naturally occurring dopamine receptor D1 agonist and D2 antagonist},
  author={S Natesan and Greg E. Reckless and Karen B. L. Barlow and John Odontiadis and Jos{\'e} N. Nobrega and Glen B Baker and Susan R. George and David C. Mamo and Shitij Kapur},
  journal={Psychopharmacology},
  year={2008},
  volume={199},
  pages={275-289}
}
l-Stepholidine, a dopamine D2 antagonist with D1 agonist activity, should in theory control psychosis and treat cognitive symptoms by enhancing cortical dopamine transmission. Though several articles describe its impact on the dopamine system, it has not been systematically evaluated and compared to available antipsychotics. We examined its in vitro interaction with dopamine D2 and D1 receptors and compared its in vivo pharmacokinetic profile to haloperidol (typical) and clozapine (atypical) in… CONTINUE READING
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