The antipsychotic drug risperidone interacts with auto- and hetero-receptors regulating serotonin output in the rat frontal cortex

@article{Hertel1999TheAD,
  title={The antipsychotic drug risperidone interacts with auto- and hetero-receptors regulating serotonin output in the rat frontal cortex},
  author={Peter Hertel and G. Nomikos and Torgny H. Svensson},
  journal={Neuropharmacology},
  year={1999},
  volume={38},
  pages={1175-1184}
}

Receptor-mediated regulation of serotonin output in the rat dorsal raphe nucleus: effects of risperidone

The findings suggest a regulatory role of local 5-HT1B/D receptors on 5- HT efflux as well as cell firing in the DRN and indicate that risperidone may interfere with the regulation of5-HT availability in this area primarily via blockade of 5-ht1D receptors.

Extracellular serotonin in the prefrontal cortex is limited through terminal 5-HT1B autoreceptors: a microdialysis study in knockout mice

The present study shows that terminal 5- HT1B autoreceptors play a significant role in the regulation of 5-HT release in the prefrontal cortex.

5-HT1B receptors and serotonin function : microdialysis studies in rats and knockout mice

The studies in mice and rats described in this thesis clearly show that 5-HT1B autoreceptors limit the acute effects of local administration of a SSRI in the hippocampus and frontal cortex and an increased response to SSRIs may be expected.

Role of extracellular serotonin levels in the effect of 5-HT1B receptor blockade

The results provide circumstantial evidence that the effect of a 5-HT1B receptor antagonist depends on extracellular 5- HT levels, but strongly suggest that additional5-HT reuptake inhibition is required to detect any effect of 5-ht1B cannabinoid receptor antagonist on 4-HT levels by in vivo microdialysis.

Adjunctive alpha2-adrenoceptor blockade enhances the antipsychotic-like effect of risperidone and facilitates cortical dopaminergic and glutamatergic, NMDA receptor-mediated transmission.

It is proposed that the therapeutic effect of risperidone in schizophrenia can be enhanced and its extrapyramidal side-effect liability reduced by adjunctive treatment with an alpha2-adrenoceptor antagonist, and generally support the notion that the potent alpha1-adRenoceptor antagonistic action of clozapine may be highly important for its unique efficacy in schizophrenia.

A Novel Approach to the Identification of Psychiatric Drugs: Serotonin-Glutamate Interactions in the Prefrontal Cortex

It is suggested that elucidation of the specific receptors that suppress glutamate release induced by 5-HT2A receptor activation in the medial prefrontal cortex may lead to novel therapeutic targets for depression, such as metabotropic glutamate agonists which may not be efficacious in screening strategies primarily dependent on synaptic availability of monoaminergic neurotransmitters.

Distinct electrophysiological effects of paliperidone and risperidone on the firing activity of rat serotonin and norepinephrine neurons

The capacity of paliperidone to reverse the selective serotonin reuptake inhibitor (SSRI)-induced inhibition of NE neuronal firing, without interfering with the effect of SSRIs of 5-HT neuronal activity, suggests that palipersidone may be a very effective adjunct in SSRI-resistant depression.

Effects of Sustained Administration of Quetiapine Alone and in Combination with a Serotonin Reuptake Inhibitor on Norepinephrine and Serotonin Transmission

Sustained administration of hQuet and N-Desalkyl quetiapine in rats in a 3 : 1 mixture significantly enhanced the firing rate of norepinephrine neurons and enhanced 5-HT transmission, which may contribute to its antidepressant action in mood disorders.

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