The antipsoriatic drug metabolite etretin (Ro 10-1670) alters the metabolism of fatty acids in human keratinocytes in culture

@article{Punnonen2004TheAD,
  title={The antipsoriatic drug metabolite etretin (Ro 10-1670) alters the metabolism of fatty acids in human keratinocytes in culture},
  author={K. Punnonen and T. Puustinen and C. T. Jans{\'e}n},
  journal={Archives of Dermatological Research},
  year={2004},
  volume={280},
  pages={103-107}
}
  • K. Punnonen, T. Puustinen, C. T. Jansén
  • Published 2004
  • Biology, Medicine
  • Archives of Dermatological Research
  • SummaryWe have studied the effect of etretin (Ro 10-1670), the active metabolite of the widely used antipsoriatic drug etretinate (Ro 10-9359), on the incorporation and release of arachidonic acid in human skin keratinocytes. During 24-h culture, radioactive 14C-arachidonic acid was avidly incorporated into the cellular lipids of the keratinocytes. When the cells were cultured for another 48 h in fresh medium, 8.8%±0.3% of the incorporated radioactivity was released from the cells. The presence… CONTINUE READING
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