The antiproteinuric effect of angiotensin antagonism in human IgA nephropathy is potentiated by indomethacin.

@article{Perico1998TheAE,
  title={The antiproteinuric effect of angiotensin antagonism in human IgA nephropathy is potentiated by indomethacin.},
  author={Norberto Perico and Andrea Remuzzi and Fabio Sangalli and Nadia Azzollini and Marilena Mister and Piero Ruggenenti and Giuseppe Remuzzi},
  journal={Journal of the American Society of Nephrology : JASN},
  year={1998},
  volume={9 12},
  pages={2308-17}
}
Evidence is available from animal and human studies that protein traffic through the glomerular capillary has a pathogenetic role in subsequent renal damage and that angiotensin-converting enzyme (ACE) inhibitors appear superior to other drugs in lowering proteinuria and the rate of renal function decline. This study compares the effect of ACE inhibition or angiotensin II (AngII) receptor blockade on urinary protein excretion and renal hemodynamics in 20 patients with IgA glomerulonephritis… CONTINUE READING