The antiproliferative potency of histamine antagonists correlates with inhibition of binding of [3H]-histamine to novel intracellular receptors (HIC) in microsomal and nuclear fractions of rat liver.

@article{Brandes1991TheAP,
  title={The antiproliferative potency of histamine antagonists correlates with inhibition of binding of [3H]-histamine to novel intracellular receptors (HIC) in microsomal and nuclear fractions of rat liver.},
  author={LorneJ. Brandes and James R Davie and Frixos Paraskevas and Balram Sukhu and Radovan Bogdanovi{\'c} and F. S. Labella},
  journal={Agents and actions. Supplements},
  year={1991},
  volume={33},
  pages={
          325-42
        }
}
  • LorneJ. Brandes, James R Davie, +3 authors F. S. Labella
  • Published in
    Agents and actions…
    1991
  • Biology, Medicine
  • Previously, we identified in rat liver microsomes, low (microM) affinity histamine receptors (HIC), associated with antiestrogen binding sites (AEBS). N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine HCl (DPPE), a potent AEBS ligand, is a specific HIC antagonist. Through binding HIC, newly-formed intracellular histamine mediates, and DPPE inhibits, human platelet aggregation. We now provide evidence that histamine, mobilized from cytoplasmic stores, is a mediator of the mitogenic response to… CONTINUE READING

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