The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice.

@article{Yoneda1991TheAE,
  title={The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice.},
  author={Toshiyuki Yoneda and Raymond M. Lyall and M Merc{\`e} Alsina and Paul E. Persons and Alfred P. Spada and Alexander Levitzki and Asher Zilberstein and Gregory R. Mundy},
  journal={Cancer research},
  year={1991},
  volume={51 16},
  pages={4430-5}
}
Many human tumors of epithelial origin contain cells overexpressing the epidermal growth factor (EGF) receptor, and there is convincing evidence that cancer cell growth is correlated with the loss of the normal regulation of the EGF receptor signal transduction pathway. Some cancers are clearly dependent on activation of the EGF receptor for their proliferation. Recently, a class of compounds, tyrphostins, which inhibit the protein tyrosine kinase activity of the growth factor receptor, have… CONTINUE READING