• Corpus ID: 1168721

The antiproliferative effect of coumarins on several cancer cell lines.

@article{Kawaii2001TheAE,
  title={The antiproliferative effect of coumarins on several cancer cell lines.},
  author={Satoru Kawaii and Yasuhiko Tomono and Kazunori Ogawa and Minoru Sugiura and Masamichi Yano and Yuya Yoshizawa},
  journal={Anticancer research},
  year={2001},
  volume={21 2A},
  pages={
          917-23
        }
}
Twenty-one coumarins were examined for their antiproliferative activity towards several cancer cell lines, namely lung carcinoma (A549), melanin pigment producing mouse melanoma (B16 melanoma 4A5), human T-cell leukemia (CCRF-HSB-2), and human gastric cancer, lymph node metastasized (TGBC11TKB). The structure-activity relationship established from the results revealed that the 6,7-dihydroxy moiety had an important role for their antiproliferative activity. Analysis of cell cycle distribution… 
View on PubMed
70 Citations
Highly Influential Citations
1
Background Citations
18
Results Citations
1

70 Citations

Synthesis of novel benzofurocoumarin analogues and their anti-proliferative effect on human cancer cell lines.

Synthesis of novel psoralen analogues and their in vitro antitumor activity.

Relationship Between the Structure of Alkylpsoralens and Their Antiproliferative Activity in HL60 Cells

Background/Aim: As part of our continuing investigation in coumarin derivatives as potential anticancer substances, a series of alkylpsoralens were synthesized, and their antiproliferative activity…

Geranylated 4-Phenylcoumarins Exhibit Anticancer Effects against Human Prostate Cancer Cells through Caspase-Independent Mechanism

Geranylated 4-phenylcoumarins isolated from Mesua elegans showed ability to activate multiple death pathways involving autophagy, lysosomal and endoplasmic reticulum death proteins which could potentially be manipulated to develop anti-cancer therapy in apoptosis resistant cells.

Apoptosis and cell cycle disturbances induced by coumarin and 7-hydroxycoumarin on human lung carcinoma cell lines.

Antimetastatic, antineoplastic, and toxic effects of 4-hydroxycoumarin in a preclinical mouse melanoma model

The data suggest that 4-HC may lead to the development of agents that could be used as adjuvants in the therapy of melanoma, and effectively reduces tumor growth and improves survival, even when it produce toxic effects.

Effects of coumarin and 7OH‐coumarin on bcl‐2 and Bax expression in two human lung cancer cell lines in vitro

  • C.M. Elinos‐BáezF. LeónE. Santos
  • Biology, Chemistry
    Cell biology international
  • 2005

Antiproliferative, cytotoxic and antitumour activity of coumarins isolated from Calophyllum brasiliense

The cytological study showed that coumarins from C. brasiliense reduce the survival of BMK cells by inducing apoptosis and, to a lesser degree, necrosis and they might increase the effectiveness of other treatments for cancer.

Coumarins and Gastrointestinal Cancer: A New Therapeutic Option?

The therapeutic effects of coumarin and its derivatives against GI cancer are summarized.

4-Hydroxycoumarin Effects on Both Cellular and Genetic Characteristics of Hepatocellular Carcinoma Cells

According to the cellular and genetic perspective, 4-Hydroxycoumarin might be useful to treat hepatocellular carcinoma and genes which are key features of cellular survival mechanisms are found.
...