The antiproliferative and apoptotic effects of apigenin on glioblastoma cells.

@article{Stump2017TheAA,
  title={The antiproliferative and apoptotic effects of apigenin on glioblastoma cells.},
  author={Trevor A. Stump and Brittany N Santee and Lauren P Williams and Rachel A Kunze and Chelsae E Heinze and Eric D Huseman and Rebecca J. Gryka and Denise S. Simpson and Samson Amos},
  journal={The Journal of pharmacy and pharmacology},
  year={2017},
  volume={69 7},
  pages={
          907-916
        }
}
OBJECTIVES Glioblastoma (GBM) is highly proliferative, infiltrative, malignant and the most deadly form of brain tumour. The epidermal growth factor receptor (EGFR) is overexpressed, amplified and mutated in GBM and has been shown to play key and important roles in the proliferation, growth and survival of this tumour. The goal of our study was to investigate the antiproliferative, apoptotic and molecular effects of apigenin in GBM. METHODS Proliferation and viability tests were carried out… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 34 REFERENCES

Therapeutic control and resistance of the EGFR-driven signaling network in glioblastoma

F Azuaje
  • Cell Commun Signal 2015;
  • 2015
VIEW 11 EXCERPTS
HIGHLY INFLUENTIAL

Garland Science, 2002

Alberts B et al. Molecular Biology of the Cell, NY 4th edn . New York
  • Chapter 17, Programmed Cell Death (Apoptosis). http://www.ncbi.nlm.nih.gov/books/NBK 26873/
  • 2016
VIEW 2 EXCERPTS