The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines.

@article{Kuo2002TheAA,
  title={The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines.},
  author={Po-Lin Kuo and Ta-chen Lin and Chun-ching Lin},
  journal={Life sciences},
  year={2002},
  volume={71 16},
  pages={
          1879-92
        }
}
The aim of this study is to investigate the anticancer effect of aloe-emodin in two human liver cancer cell lines, Hep G2 and Hep 3B. We observed that aloe-emodin inhibited cell proliferation and induced apoptosis in both examined cell lines, but with different the antiproliferative mechanisms. In Hep G2 cells, aloe-emodin induced p53 expression and was accompanied by induction of p21 expression that was associated with a cell cycle arrest in G1 phase. In addition, aloe-emodin had a marked… Expand
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Aloe-emodin induced in vitro G2/M arrest of cell cycle in human promyelocytic leukemia HL-60 cells.
  • H. Chen, W. Hsieh, W. C. Chang, J. Chung
  • Biology, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2004
TLDR
Aloe-emodin appears to exert its anticarcinogenesis properties by inhibiting proliferation and inducing cell cycle arrest and apoptosis underwent activation of caspase-3 in human leukemia HL-60 cells. Expand
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TLDR
It is demonstrated that aloe-emodin induced cell death in a dose- and time-dependent manner and that the AGS cells were generally more sensitive than the NCI-N87 cells. Expand
Aloe-Emodin Induces Breast Tumor Cell Apoptosis through Upregulation of miR-15a/miR-16-1 That Suppresses BCL2
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Enhanced induction of cell cycle arrest and apoptosis via the mitochondrial membrane potential disruption in human U87 malignant glioma cells by aloe emodin
TLDR
Aloe emodin showed a time- and dose-dependent inhibition of U 87 cells proliferation and decreased the percentage of viable U87 cells via the induction of apoptosis and arrested the cell cycle in the S phase, demonstrating the early event of the mitochondria-induced apoptotic pathway. Expand
Aloe-emodin Induces Apoptosis through the Up-Regulation of Fas in the Human Breast Cancer Cell Line MCF-7
TLDR
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Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation
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These findings provide a possible mechanistic explanation for the growth inhibitory effect of aloe-emodin on HeLa, which includes cell cycle arrest and inducing differentiation. Expand
Cell cycle arrest and apoptosis induced by aspidin PB through the p53/p21 and mitochondria-dependent pathways in human osteosarcoma cells
TLDR
The reported induced cell cycle arrest and apoptosis through the p53/p21 and mitochondria-dependent pathways in human osteosarcoma cells and the role of siRNA targeted to p53 led to a dose-dependent attenuation of aspidin PB-induced apoptosis signaling is concluded. Expand
Mechanism of Aloe Emodin-Induced Apoptosis in ER+-Breast Cancer Cells, MCF-7
The objective of this research is to investigate the regulation of apoptotic associated-genes and proteins expression of aloe emodin on oestrogen receptor (ER)-positive (MCF-7). Oestrogen receptor… Expand
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