The antiplatelet effects of a new nitroderivative of acetylsalicylic acid--an in vitro study of inhibition on the early phase of platelet activation and on TXA2 production.

@article{Lechi1996TheAE,
  title={The antiplatelet effects of a new nitroderivative of acetylsalicylic acid--an in vitro study of inhibition on the early phase of platelet activation and on TXA2 production.},
  author={Clara Lechi and Giuseppe Andrioli and Stefania Gaino and Rosa Maria Tommasoli and Valeria Zuliani and Riccardo Ortolani and Maurizio Degan and G{\"o}ran Benoni and Paolo Bellavite and Alessandro Lechi and Pietro Minuz},
  journal={Thrombosis and haemostasis},
  year={1996},
  volume={76 5},
  pages={791-8}
}
We studied in vitro the antiplatelet activity of a new nitroderivative chemically related to acetylsalicylic acid: 2 acetoxybenzoate 2-[1-nitroxy-methyl]-phenyl ester (NCX 4016), in order to identify any effects due to the release of nitric oxide and the blockade of cyclo-oxygenase. The effects of scalar doses of NCX 4016 on the early phase of platelet activation, platelet aggregation and thromboxane A2 production were investigated. We observed inhibitory effects of NCX 4016 on platelet… CONTINUE READING