The antiplatelet effect of clopidogrel is not attenuated by statin treatment in stable patients with ischemic heart disease.

Abstract

Recent studies suggest that cytochrome P450 (CYP) 3A4 metabolized statins attenuate the antiaggregatory effect of clopidogrel. We evaluated how CYP3A4 metabolized statins and non-CYP3A4 metabolized statins influence platelet aggregation when given concomitantly with clopidogrel. Sixty-six stable patients with ischemic heart disease were included in this… (More)

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@article{Vinholt2005TheAE, title={The antiplatelet effect of clopidogrel is not attenuated by statin treatment in stable patients with ischemic heart disease.}, author={Pernille Just Vinholt and Tina Svenstrup Poulsen and Lars Korsholm and S\oren Risom Kristensen and Jesper Hallas and Per Damkier and Hans F Mickley}, journal={Thrombosis and haemostasis}, year={2005}, volume={94 2}, pages={438-43} }