The antiplasmodial activity of spermine alkaloids isolated from Albizia gummifera.

@article{Rukunga2007TheAA,
  title={The antiplasmodial activity of spermine alkaloids isolated from Albizia gummifera.},
  author={G M Rukunga and Francis W Muregi and Festus Mururi. Tolo and Samar Abdelaziz Omar and Peter Mwitari and Charles N. Muthaura and François X. Omlin and Teresa O. Akenga and Ahmed Hassanali and John I. Githure and Fuad A. Iraqi and G. M. Patrick Mungai and Wolfgang Ina Kraus and W M Kofi-Tsekpo},
  journal={Fitoterapia},
  year={2007},
  volume={78 7-8},
  pages={
          455-9
        }
}
In the present study the methanolic extract of Albizia gummifera was fractionated into various fractions. These fractions were tested against choroquine sensitive (NF54) and resistant (ENT30) strains of Plasmodium falciparum. All other fractions apart from the alkaloidal fraction showed low activity with IC 50 above 3 microg/ml. The alkaloidal fraction exhibited strong activity against NF54 and ENT30 with IC 50 of 0.16+/-0.05 and 0.99+/-0.06 microg/ml, respectively. Five known spermine… CONTINUE READING
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