The antiphospholipid syndrome and heart valve surgery.

@article{Gorki2008TheAS,
  title={The antiphospholipid syndrome and heart valve surgery.},
  author={Hagen Gorki and Vitali Malinovski and Rex de Lisle Stanbridge},
  journal={European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery},
  year={2008},
  volume={33 2},
  pages={
          168-81
        }
}
The antiphospholipid syndrome (APLS) is a complex autoimmune disease often connected to systemic lupus erythematodes. Main features are thromboses, fetal loss and specific antibodies. The involved autoantibodies are directed against plasma proteins such as beta2glycoprotein1 (beta2GPI) or prothrombin which depend on negatively charged phospholipids. Direct antibodies against phospholipids are of no importance for APLS. Clotting tests such as activated partial thromboplastin time or diluted… CONTINUE READING
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Pathophysiology of the antiphospholipid syndrome

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