The antiparasitic drug niclosamide inhibits dengue virus infection by interfering with endosomal acidification independent of mTOR

  title={The antiparasitic drug niclosamide inhibits dengue virus infection by interfering with endosomal acidification independent of mTOR},
  author={Jo-Chi Kao and Wei-Chun HuangFu and Tsung‐Ting Tsai and Min-Ru Ho and Ming-Kai Jhan and Ting-Jing Shen and Po‐Chun Tseng and Yung-Ting Wang and Chiou-Feng Lin},
  journal={PLoS Neglected Tropical Diseases},
Background The antiparasitic agent niclosamide has been demonstrated to inhibit the arthropod-borne Zika virus. Here, we investigated the antiviral capacity of niclosamide against dengue virus (DENV) serotype 2 infection in vitro and in vivo. Principle finding Niclosamide effectively retarded DENV-induced infection in vitro in human adenocarcinoma cells (A549), mouse neuroblastoma cells (Neuro-2a), and baby hamster kidney fibroblasts (BHK-21). Treatment with niclosamide did not retard the… 

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