The antioxidant paradox in diabetes mellitus.

  title={The antioxidant paradox in diabetes mellitus.},
  author={Mae Sheikh-Ali and Joe M. Chehade and Arshag D Mooradian},
  journal={American journal of therapeutics},
  volume={18 3},
There is ample empiric evidence to indicate that oxidative stress contributes to the pathogenesis of coronary artery disease and has a key role in the onset and progression of diabetes and its complications. Diabetes leads to depletion of the cellular antioxidant defense system and is associated with an increase in the production of free radicals. Oxidative stress can be the result of multiple pathways. Some of these are related to substrate-driven overproduction of mitochondrial reactive… CONTINUE READING
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