The antioxidant glutathione peroxidase family and spermatozoa: A complex story

@article{Drevet2006TheAG,
  title={The antioxidant glutathione peroxidase family and spermatozoa: A complex story},
  author={Joel R. Drevet},
  journal={Molecular and Cellular Endocrinology},
  year={2006},
  volume={250},
  pages={70-79}
}
  • J. Drevet
  • Published 2006
  • Biology, Medicine
  • Molecular and Cellular Endocrinology
Oxidative damage is one threat spermatozoa have to face during epididymal maturation and storage. However, it is clear that reactive oxygen species (ROS) are also central for sperm physiology in processes such as sperm maturation and capacitation. It is therefore essential that there exists around sperm cells a fine balance between ROS production and recycling. To do so, sperm cells and epididymal epithelial cells rely on common enzymatic ROS scavengers such as superoxide dismutase (SOD… Expand
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249 Citations
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249 Citations

Citation Type

Citation Type

Mammalian glutathione peroxidases control acquisition and maintenance of spermatozoa integrity.
TLDR
The importance of the GPx protein family in determining the fertilizing potential of mammalian spermatozoa is underlined in the field of mammalian fertility and infertility as well as in the development of assisted medical procreation technologies and male gamete preservation techniques that are extensively used in human and animal reproduction programs. Expand
Glutathione peroxidases at work on epididymal spermatozoa: an example of the dual effect of reactive oxygen species on mammalian male fertilizing ability.
TLDR
The roles played by the sperm-associated forms of GPx4, the secreted GPx5 protein, and the epithelial proteins GPx1, GPx3, and cellular GPx2 are reviewed, all functioning in the mammalian epididymis at different stages of the sperm's epidIDymal journey, and in different epididcyis compartments. Expand
Leukocytes and oxidative stress: dilemma for sperm function and male fertility.
  • R. Henkel
  • Biology, Medicine
  • Asian journal of andrology
  • 2011
TLDR
A proper andrological diagnostic work-up, including the evaluation of ROS levels and the antioxidant capacity of the semen, has to be carried out beforehand, aimed at keeping the fine balance between oxidation and scavenging of vital amounts of ROS. Expand
Role of oxidative stress and antioxidants in domestic and non-domestic cat spermatozoa
Living cells, including spermatozoa, stored under aerobic conditions require oxygen to support their normal metabolism. Excessive levels of metabolites (reactive oxygen species; ROS) can cause cell… Expand
Role of residual cytoplasm on oxidative status during sperm maturation in dogs.
TLDR
During maturation sperm cells acquire their fertilizing ability, but this event also produces reactive oxygen species and as such local antioxidant protection is required, indicating the physiological need of the specific antioxidants in these segments of the epididymis. Expand
Role of Oxidative Stress and Antioxidants in Domestic and Non- Domestic Cat Spermatozoa With special reference to cryopreservation
Living cells, including spermatozoa, stored under aerobic conditions require oxygen to support their normal metabolism. Excessive levels of metabolites (reactive oxygen species; ROS) can cause cell… Expand
Cryopreservation of epididymal cat spermatozoa: effects of in vitro antioxidative enzymes supplementation and lipid peroxidation induction.
TLDR
It is concluded that glutathione peroxidase exhibits positive effects on post-thaw epididymal cat spermatozoa and the lipid peroxidation reaction induced by a transition metal (ferrous ion (II); Fe(2+)) on sperm quality during the cryopreservation process, but none among the selected antioxidative enzymes could improve all sperm quality parameters. Expand
Proteomic analysis of boar spermatozoa and quantity changes of superoxide dismutase 1, glutathione peroxidase, and peroxiredoxin 5 during epididymal maturation.
TLDR
It is concluded that several antioxidant proteins increase during the transit of boar spermatozoa through the epididymis, ultimately contributing to the maturation and/or survival of sperm. Expand
Functions and effects of reactive oxygen species in male fertility.
TLDR
This review paper will focus on describing the predominant sources of ROS in the ejaculate, the effects of ROS on a cellular and molecular level, and the actions of ROS from the whole animal perspective. Expand
Induced lipid peroxidation in ram sperm: semen profile, DNA fragmentation and antioxidant status.
TLDR
An increase in native GPx activity and CAT immunodetection in groups with high susceptibility to induced lipid peroxidation is observed, which may be the main cause of chromatin damage in ram sperm. Expand
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