The antioxidant function of the physiological content of vitamin C.

@article{Glascott1996TheAF,
  title={The antioxidant function of the physiological content of vitamin C.},
  author={P A Glascott and Mariya Tsyganskaya and E Gilfor and Mark A. Zern and John L. Farber},
  journal={Molecular pharmacology},
  year={1996},
  volume={50 4},
  pages={994-9}
}
The synthesis of vitamin C is substantially reduced in Osteogenic Disorder Shionogi (ODS) rats. Hepatocytes prepared from these rats contained approximately 12% of the wild-type content of this vitamin. In culture, the ascorbate content remained low in the absence of supplementation of the medium. Independent of their vitamin C status, cultured hepatocytes become depleted of vitamin E. Supplementation of the culture medium with 10C microM ascorbate and 1.2 microM alpha-tocopherol phosphate… CONTINUE READING