The antioxidant function of the p53 tumor suppressor

  title={The antioxidant function of the p53 tumor suppressor},
  author={Anna A. Sablina and Andrei V. Budanov and Galina V. Ilyinskaya and Larissa S. Agapova and Julia Evgenyevna Kravchenko and Peter M Chumakov},
  journal={Nature Medicine},
It is widely accepted that the p53 tumor suppressor restricts abnormal cells by induction of growth arrest or by triggering apoptosis. Here we show that, in addition, p53 protects the genome from oxidation by reactive oxygen species (ROS), a major cause of DNA damage and genetic instability. In the absence of severe stresses, relatively low levels of p53 are sufficient for upregulation of several genes with antioxidant products, which is associated with a decrease in intracellular ROS… CONTINUE READING
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