The antioxidant effects of a novel iron chelator salicylaldehyde isonicotinoyl hydrazone in the prevention of H(2)O(2) injury in adult cardiomyocytes.

@article{Horackova2000TheAE,
  title={The antioxidant effects of a novel iron chelator salicylaldehyde isonicotinoyl hydrazone in the prevention of H(2)O(2) injury in adult cardiomyocytes.},
  author={Magda Horackova and Premysl Ponka and Zenobia Byczko},
  journal={Cardiovascular research},
  year={2000},
  volume={47 3},
  pages={529-36}
}
OBJECTIVE This study was designed to investigate the cardioprotective effect of the novel lipophilic iron chelator salicylaldehyde isonicotinoyl hydrazone (SIH) against the oxidative stress exerted by H(2)O(2) through the production of OH radical via the Fenton reaction and to compare them with those of the hydrophilic iron chelator deferoxamine (DFO) and the Na(+)/H(+) exchange inhibitor methylisobutyl amiloride (MIA). METHODS We used long-term cultures of spontaneously beating adult guinea… CONTINUE READING
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