The antioxidant effect of DL-alpha-lipoic acid on copper-induced acute hepatitis in Long-Evans Cinnamon (LEC) rats.

@article{Yamamoto2001TheAE,
  title={The antioxidant effect of DL-alpha-lipoic acid on copper-induced acute hepatitis in Long-Evans Cinnamon (LEC) rats.},
  author={Hirofumi Yamamoto and Toshiaki Watanabe and Hiromi Mizuno and Kazutoyo Endo and Jun-ichiro Fukushige and Tomoyoshi Hosokawa and Akio Kazusaka and Shuzo Fujita},
  journal={Free radical research},
  year={2001},
  volume={34 1},
  pages={69-80}
}
The Long-Evans Cinnamon (LEC) rats, due to a genetic defect, accumulate excess copper (Cu) in the liver in a manner similar to patients with Wilson's disease and spontaneously develop acute hepatitis with severe jaundice. In this study we examined the protective effect of DL-alpha-Lipoic acid (LA) against acute hepatitis in LEC rats. LA was administered to LEC rats by gavage in doses of 10, 30 and 100 mg/kg five times per week, starting at 8-weeks-old and continuing till 12-weeks-old. Although… CONTINUE READING

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