The antioxidant drug dipyridamole spares the vitamin E and thiols in red blood cells after oxidative stress.

  title={The antioxidant drug dipyridamole spares the vitamin E and thiols in red blood cells after oxidative stress.},
  author={Claudia Kusmic and Eugenio Picano and Carla L Busceti and C. Petersen and Renata Barsacchi},
  journal={Cardiovascular research},
  volume={47 3},
OBJECTIVE To test the antioxidant effect of therapeutic doses of dipyridamole on cellular membranes, human erythrocytes were chosen as an appropriate model to study oxidative stress induced by cumene hydroperoxide because of their high content in heme-Fe(2+). METHODS The oxidative stress was induced by incubation with 160 micromoll(-1) cumene hydroperoxide and expressed by three main factors: lipid peroxidation by means of kinetics of decrease in fluorescence emission of the probe… CONTINUE READING
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