The antioxidant capacity of saliva.

  title={The antioxidant capacity of saliva.},
  author={Maurizio Antonio Battino and Maria Soledad Ferreiro and Isabel Gallardo and Hubert N. Newman and Pedro Bull{\'o}n},
  journal={Journal of clinical periodontology},
  volume={29 3},
BACKGROUND/AIMS Saliva, a heterogeneous fluid comprising proteins, glycoproteins, electrolytes, small organic molecules and compounds transported from the blood, constantly bathes the teeth and oral mucosa. It acts as a cleansing solution, an ion reservoir, a lubricant and a buffer. In addition to its other host-protective properties, saliva could constitute a first line of defence against free radical-mediated oxidative stress, since the process of mastication and digestion of ingested foods… 


The results illustrate that OS caused a depletion of antioxidant status in the oral cavity, and Uric acid, albumin and TAC are very important and promising salivary biomarkers for monitoring the oral OS.

Antioxidant Capacity of Saliva: Effect on Onset and Progression of Dental Caries

The total antioxidant capacity (TAC) is a biomarker often used to investigate the oxidative stress and can be collected noninvasively and be used as a diagnostic fluid for detecting biomarkers of various pathological conditions.

Activity of enzymatic antioxidants in periodontitis: A systematic overview of the literature.

The aim of this systematic overview of the literature was to present the current research on the activity of these antioxidant enzymes in the gingival fluid, saliva and blood serum of patients with periodontitis.

Saliva--a diagnostic window to the body, both in health and in disease.

As a diagnostic fluid, saliva offers distinctive advantages over serum, and may provide a cost-effective approach for the screening of large populations, and could have a significant role in controlling and/or modulating oxidative damages in the oral cavity.

Salivary markers of oxidative stress in oral diseases

Basic information on the most commonly used salivary markers of oxidative damage, antioxidant status, and carbonyl stress is summarized and the studies analyzing these markers in patients with caries or periodontitis are analyzed.

Action of an antioxidant complex on the antioxidant power of saliva.

It is indicated that antioxidant levels can be increased with specific nutritional supplement and the clinical value of an increased antioxidant power in biological fluids, particularly in saliva, may be relevant for future trials of prevention and treatment.

Total antioxidant capacity of saliva and its relation with early childhood caries and rampant caries.

The results indicated that the total antioxidant capacity (TAC) of saliva increased in children with caries and also increased with the age of the children.

Total antioxidant capacity, lipid peroxidation and uric acid of saliva in smokers and non-smokers: a comparative study

The result of this study indicates that smoking can reduce total antioxidant capacity and increase lipid peroxidation parameters in smokers and non-smoking persons.

Salivary Redox Biomarkers in the Course of Caries and Periodontal Disease

Caries are a pathological process of extracorporeal nature, characterized by demineralization of inorganic substances as well as proteolysis triggered by acids produced by bacteria present in dental

Antioxidative Effect of Human Saliva on Lipid Peroxidation

The results strongly suggest that humansaliva has a role in suppressing the lipid peroxidation of ingested foods.

Antioxidant activity of saliva and periodontal disease.

The antioxidant potential of saliva does not appear to be compromised in patients with periodontal disease but this may relate to the antioxidant flow from the gingival crevicular fluid.

Antioxidant status and dialysis: plasma and saliva antioxidant activity in patients with fluctuating urate levels.

There is evidence that both total protein concentration and uric acid level show a good correlation with saliva total antioxidant capacity, suggesting that proteins are major antioxidants of this fluid.

Reactive oxygen species and antioxidants in inflammatory diseases.

  • I. Chapple
  • Biology
    Journal of clinical periodontology
  • 1997
The rôle of free radical-induced tissue damage and antioxidant defence mechanisms in inflammatory diseases that involve pathogenic processes similar to the periodontal diseases are reviewed and it is hypothesised that NF-kappa B antagonists may offer important therapeutic benefits.

Saliva: its secretion, composition and functions

  • W. Edgar
  • Medicine
    British Dental Journal
  • 1992
The physiology of the secretory process, the reflex control of whole saliva flow rate, the composition of the fluid, the factors affecting its composition, and the functions of the organic and inorganic components are described.

Enhanced Chemiluminescent Assay for Measuring the Total Antioxidant Capacity of Serum, Saliva and Crevicular Fluid

The ECL assay described provides a rapid, simple and reproducible method of measuring total antioxidant defence in small volumes of biological fluids.

Total antioxidant status in plasma and body fluids.

Multicomponent spectroscopic investigations of salivary antioxidant consumption by an oral rinse preparation containing the stable free radical species chlorine dioxide (ClO2.).

A multicomponent evaluation of the oxidative consumption of salivary biomolecules by a commercially-available oral rinse preparation containing an admixture of the stable free radical species

Oxidative injury and inflammatory periodontal diseases: the challenge of anti-oxidants to free radicals and reactive oxygen species.

Current evidence for oxidative damage in chronic inflammatory periodontal disease, and the possible therapeutic effects of anti-oxidants in treating and/or preventing such pathology, are reviewed, with special attention to vitamin E and Co-enzyme Q.

Evaluation of plasma low molecular weight antioxidant capacity by cyclic voltammetry.