The antioxidant activity of haptoglobin towards haemoglobin-stimulated lipid peroxidation.

@article{Gutteridge1987TheAA,
  title={The antioxidant activity of haptoglobin towards haemoglobin-stimulated lipid peroxidation.},
  author={John M C Gutteridge},
  journal={Biochimica et biophysica acta},
  year={1987},
  volume={917 2},
  pages={219-23}
}
Haemoglobin stimulates the peroxidation of lipids in two discernable phases. The first phase is inhibited by binding haemoglobin to the protein haptoglobin. The second phase is stimulated by complexable iron released from the haemoglobin molecule during the process of lipid peroxidation. This latter peroxidation is inhibitable by transferrin and the iron chelator desferrioxamine. Heat-denatured haemoglobin and haemin both stimulated lipid peroxidation but this is not inhibitable by haptoglobin… CONTINUE READING

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