The antinociceptive properties of reboxetine in acute pain

@article{Schreiber2009TheAP,
  title={The antinociceptive properties of reboxetine in acute pain},
  author={Shaul Schreiber and Ruthi Frishtick and Ina Volis and V Rubovitch and Chaim G. Pick and Ronit Weizman},
  journal={European Neuropsychopharmacology},
  year={2009},
  volume={19},
  pages={735-739}
}
The antinociceptive effects of the selective noradrenaline reuptake inhibitor antidepressant reboxetine and its interaction with various opioid and noradrenaline receptor subtypes were evaluated. Reboxetine (i.p.) induced a weak dose-dependent antinociceptive effect in acute pain, using the hotplate model. The reboxetine-induced antinociception was significantly inhibited by the opioid receptor antagonists naloxone, nor-BNI, naltrindole and b-FNA, implying a non-selective role for the opioid… Expand
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References

SHOWING 1-10 OF 47 REFERENCES
The antinociceptive effect of venlafaxine in mice is mediated through opioid and adrenergic mechanisms
TLDR
The antinociceptive effect of venlafaxine is mainly influenced by the kappa- and delta-opioid receptor subtypes combined with the alpha2-adrenergic receptor, suggesting a potential use in the management of some pain syndromes. Expand
The antinociceptive effect of mirtazapine in mice is mediated through serotonergic, noradrenergic and opioid mechanisms
TLDR
The antinociceptive effect of mirtazapine is mainly influenced by the kappa(3)-opioid receptor subtype combined with both serotonergic and noradrenergic receptors, suggesting a potential use in the management of some pain syndromes and raising questions regarding a possible indirect opioid-dependence induced by mirtzapine. Expand
A role for serotonin and beta-endorphin in the analgesia induced by some tricyclic antidepressant drugs
TLDR
The analgesic effect of clomipramine and amitriptyline and their potentiation of morphine induced analgesia seems to be related to an activation of the endogenous opioid system mediated by serotonin. Expand
Interaction between the tetracyclic antidepressant mianserin HCl and opioid receptors
TLDR
A potential use of mianserin in the management of some pain syndromes is suggested, however, further research is needed in order to establish both the exact clinical indications and the effective doses of mianerserin when prescribed for pain. Expand
From selective to highly selective SSRIs: A comparison of the antinociceptive properties of fluoxetine, fluvoxamine, citalopram and escitalopram
TLDR
Findings show that fluoxetine, fluvoxamine and citalopram given i.p. are weak antinociceptors, (not mediated through opioid mechanisms), while escitaloprams possesses no ant inociceptive properties when injected i. Expand
Amitriptyline potentiates morphine analgesia by a direct action on the central nervous system
TLDR
Results are consistent with the hypothesis that amitriptyline produces analgesia by blocking serotonin uptake and therefore enhancing the action of serotonin at the spinal terminals of an opioid‐mediated intrinsic analgeisa system. Expand
Antidepressants as analgesics: an overview of central and peripheral mechanisms of action.
TLDR
The involvement of these mechanisms in both central and peripheral analgesia produced by antidepressants is considered, as are some aspects of the mechanisms by which these actions occur. Expand
The analgesic effect of tricyclic antidepressants
TLDR
Serotonin is an important link in TCA analgesia; noradrenaline has no effect and after long-term use, amitriptyline, which acts on serotonin, had an analgesic effect and this effect was blocked by pCPA. Expand
Venlafaxine and mirtazapine: different mechanisms of antidepressant action, common opioid-mediated antinociceptive effects--a possible opioid involvement in severe depression?
TLDR
It is speculated that the involvement of the opioid system in the antidepressants' mechanism of action may be necessary, in order to prove effective in the treatment of severe depression, unlike the SSRIs and other antidepressants which lack opioid activity. Expand
Venlafaxine and mirtazapine
TLDR
It is speculated that the involvement of the opioid system in the antidepressants’ mechanism of action may be necessary, in order to prove effective in the treatment of severe depression, unlike the SSRIs and other antidepressants which lack opioid activity. Expand
...
1
2
3
4
5
...