The antinociceptive effect of tramadol on a model of neuropathic pain in rats.

@article{Apaydin2000TheAE,
  title={The antinociceptive effect of tramadol on a model of neuropathic pain in rats.},
  author={Sebnem Apaydin and Meltem Uyar and N Ulku Karabay and Elvan Erhan and Ibrahim Yegul and I. Tuğlular},
  journal={Life sciences},
  year={2000},
  volume={66 17},
  pages={1627-37}
}
The antinociceptive activity of tramadol was investigated on the vocalization threshold to paw pressure in a rat model of unilateral mononeuropathy produced by loose ligatures around the common sciatic nerve. Despite the analgesic activity of tramadol was clearly established in motor and sensory responses of the nociceptive system in rats, the effect of this atypical opioid on experimental neuropathic pain models is not investigated. The intraperitoneally injected tramadol (2.5, 5 and 10 mg/kg… CONTINUE READING

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