The antimitogenic effect of the cannabinoid receptor agonist WIN55212-2 on human melanoma cells is mediated by the membrane lipid raft.

@article{Scuderi2011TheAE,
  title={The antimitogenic effect of the cannabinoid receptor agonist WIN55212-2 on human melanoma cells is mediated by the membrane lipid raft.},
  author={Mariagrazia Rita Scuderi and Giuseppina Cantarella and Mimmo Scollo and Laurence Lempereur and Marco Palumbo and Gloria Saccani-Jotti and Renato Bernardini},
  journal={Cancer letters},
  year={2011},
  volume={310 2},
  pages={240-9}
}
Here are reported the antiproliferative effects of the cannabinoid agonist WIN upon human melanoma cells expressing mRNA and protein for both CB1 and CB2 receptors. While WIN exerted antimitogenic effects, selective CB1 or CB2 agonists were unable to reproduce such effects and selective CB1 and CB2 antagonists did not inhibit WIN-induced cell death. Cells treated with WIN, preincubated with the lipid raft disruptor methylcyclodestrin, were rescued from death. WIN induced activation of caspases… CONTINUE READING
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