The antimicrobial protein S100A7/psoriasin enhances the expression of keratinocyte differentiation markers and strengthens the skin's tight junction barrier.

@article{Hattori2014TheAP,
  title={The antimicrobial protein S100A7/psoriasin enhances the expression of keratinocyte differentiation markers and strengthens the skin's tight junction barrier.},
  author={Fumihiro Hattori and Chanisa Kiatsurayanon and Ko Okumura and Hideoki Ogawa and Sadao Ikeda and Koichi Okamoto and François Niyonsaba},
  journal={The British journal of dermatology},
  year={2014},
  volume={171 4},
  pages={742-53}
}
BACKGROUND S100A7/psoriasin is a member of the S100 protein family and is encoded in the epidermal differentiation complex, which contains genes for markers of epidermal differentiation. S100A7/psoriasin is overexpressed in hyperproliferative skin diseases, where it is believed not only to exhibit antimicrobial functions, but also to induce immunomodulatory activities, including chemotaxis and cytokine/chemokine production. OBJECTIVES To evaluate the effect of S100A7/psoriasin on keratinocyte… CONTINUE READING
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