The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes

@inproceedings{Chindera2016TheAP,
  title={The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes},
  author={Kantaraja Chindera and Manohar Mahato and Ashwani Kumar Sharma and Harry Horsley and Klaudia Kloc-Muniak and Nor Fadhilah Kamaruzzaman and Satish Kumar and A. C. Mcfarlane and Jem Stach and Thomas Bentin and Liam Good},
  booktitle={Scientific reports},
  year={2016}
}
To combat infection and antimicrobial resistance, it is helpful to elucidate drug mechanism(s) of action. Here we examined how the widely used antimicrobial polyhexamethylene biguanide (PHMB) kills bacteria selectively over host cells. Contrary to the accepted model of microbial membrane disruption by PHMB, we observed cell entry into a range of bacterial species, and treated bacteria displayed cell division arrest and chromosome condensation, suggesting DNA binding as an alternative… CONTINUE READING

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A review

S. Wessels, Ingmer, H. Modes of action of three disinfectant active substances
  • Regul. Toxicol. Pharmacol. 67, 456–467
  • 2013

A new non-invasive approach based on polyhexamethylene biguanide increases the regression rate of HPV infection

A. Gentile, S. Gerli, G. C. Di Renzo
  • BMC Clin Pathol 12,
  • 2012