The antimicrobial peptide polyphemusin localizes to the cytoplasm of Escherichia coli following treatment.

@article{Powers2006TheAP,
  title={The antimicrobial peptide polyphemusin localizes to the cytoplasm of Escherichia coli following treatment.},
  author={J S Powers and Morgan M. Martin and Danika L. Goosney and Robert E. Hancock},
  journal={Antimicrobial agents and chemotherapy},
  year={2006},
  volume={50 4},
  pages={1522-4}
}
The horseshoe crab peptide polyphemusin I possesses high antimicrobial activity, but its mechanism of action is as yet not well defined. Using a biotin-labeled polyphemusin I analogue and confocal fluorescence microscopy, we showed that the peptide accumulates in the cytoplasm of wild-type Escherichia coli within 30 min after addition without causing substantial membrane damage. 

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