The antimicrobial natural product chuangxinmycin and some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase.

Abstract

The antimicrobial natural product chuangxinmycin has been found to be a potent and selective inhibitor of bacterial tryptophanyl tRNA synthetase (WRS). A number of analogues have been synthesised. The interaction with WRS appears to be highly constrained, as only sterically smaller analogues afforded significant inhibition. The only analogue to show… (More)

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@article{Brown2002TheAN, title={The antimicrobial natural product chuangxinmycin and some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase.}, author={Murray J B Brown and Paul S Carter and Ashley S Fenwick and Andrew P. Fosberry and Dieter W Hamprecht and Martin J Hibbs and Richard L Jarvest and Lucy Mensah and Peter H. Milner and Peter J O'Hanlon and Andrew J. Pope and Christine M. Richardson and Andrew B. West and David R Witty}, journal={Bioorganic & medicinal chemistry letters}, year={2002}, volume={12 21}, pages={3171-4} }