The antimicrobial activity of phenoxyethanol in vaccines

  title={The antimicrobial activity of phenoxyethanol in vaccines},
  author={I Lowe and Jo Southern},
  journal={Letters in Applied Microbiology},
The activity of the antimicrobial preservatives, phenoxyethanol and thiomersal, were compared in diphtheria, tetanus and pertussis (adsorbed) vaccine. Both chemicals were equally effective in inactivating challenge doses of Gram‐negative and Gram‐positive micro‐organisms, as well as a yeast. 
Influence of Temperature on the Efficacy of 2-Phenoxyethanol as a Preservative for Adsorbed Diphtheria-Purified Pertussis-Tetanus Combined Vaccine
The efficacy of two antimicrobial preservatives, 2-phenoxyethanol (2-PE) and Thimerosal, was compared in adsorbed diphtheria-purified pertussis-tetanus combined vaccine (DPT vaccine). Thimerosal hadExpand
Studies on the using of 2-Phenoxyethanol as an Alternative to Thiomersal as a Preservative in Foot-and-Mouth Disease Vaccine
The cause and the prevention measures of the pyrogen-free colored sediment that might appear in the vaccine formula were discussed and the etiology of the biological product was approached and solved. Expand
Effect of Phenoxy Ethanol in the Growth of Certain Pathogenic Microbes
Siddha system of medicine is however wonderful and miraculous, it is quite ancient andold. Hence the preparations of Siddha system of medicine may appear irrelevant if they are notmodernized andExpand
A simple and rapid method for quantifying 2-phenoxyethanol (2-PE) in Diphtheria, Tetanus and w-Pertussis (DTwP) vaccine.
  • B. Sharma, A. Joseph, A. Sood
  • Medicine
  • Biologicals : journal of the International Association of Biological Standardization
  • 2008
The authors developed a simple and rapid method for quantitation of 2-phenoxyethanol (2-PE) in DTwP vaccine based on reverse phase high performance liquid chromatography (HPLC). The method was simpleExpand
A Review of Thimerosal (Merthiolate) and its Ethylmercury Breakdown Product: Specific Historical Considerations Regarding Safety and Effectiveness
The ubiquitous and largely unchecked place of Thimerosal in pharmaceuticals, therefore, represents a medical crisis. Expand
The relative toxicity of compounds used as preservatives in vaccines and biologics.
None of the compounds commonly used as preservatives in US licensed vaccine/biological preparations can be considered an ideal preservative, and their ability to fully comply with the requirements of the US Code of Federal Regulations for preservatives is in doubt. Expand
Antimicrobials and Disinfectants
The most frequently used preservatives in cosmetics and topical drugs are parabens, imidazolinidyl urea, quaternium-15, dimethylol-dimethyl (DMDM) hydantoin, phenoxyethanol, met-hylchloroisothiazolinone/methylisothiazolone, dia-zolinids urea and sorbic acid. Expand
Vaccins de combinaison avec agent de conservation à base de 1-hydroxy-2-phénoxyéthane
La presente invention concerne des procedes de preparation de vaccins de combinaison comportant des toxoides de diphterie et tetanos, les deux toxoides etant utilises dans les procedes sous la formeExpand
Thimerosal as discrimination: vaccine disparity in the UN Minamata Convention on mercury.
A double standard in vaccine safety, which previously existed due to ignorance and economic reasons, has now been institutionalised as global policy by the Minamata Convention on Hg, condoning a two-tier standard of vaccine safety for developed nations and a predominantly thimerosal-containing one for developing nations. Expand
Generalized eczema in an 18‐month‐old boy due to phenoxyethanol in DPT vaccine
An 18-month-old boy was referred with a history of 2 episodes of generalized eczema starting within 24 h of routine administration of a DPT (diphtheria, pertussis and tetanus) vaccine (InfanrixA, SmithKline-Beecham). Expand


The addition of 0.375 per cent v/v of 2-phenoxyethanol to poliomyelitis vaccine furnished a stable mixture of preservatives which was inhibitory to both bacteria and fungi. Expand
The preservation of poliomyelitis vaccine with stabilized merthiolate.
The protective antigenicity of the vaccine against the three types of virus is maintained in accelerated aging tests at 37 ° C and the antibacterial and antifungal actions of this preservative are not diminished by the addition of EDTA. Expand
The lethal action of 2-phenoxyethanol and its analogues upon Escherichia coli NCTC 5933.
Temperature coefficients of rates of cellular leakage of low molecular weight cytoplasmic constituents, and rates of kill, were markedly different and suggested that the two phenomena were not integrally related, but that each was a consequence of some other action of the drug. Expand
Effect of phenoxyethanol on the permeability of Escherichia coli NCTC 5933 to inorganic ions.
Concentrations of phenoxyethanol which retarded the growth rate of Escherichia coli NCTC 5933 in nutrient broth, stimulated the rates of respiration and total oxygen uptake of cell suspensions withExpand
Inhibition of some respiration and dehydrogenase enzyme systems in Escherichia coli NCTC 5933 by phenoxyethanol.
Low concentrations (less than 0.2% w/v) of phenoxyethanol stimulated both the rate of respiration and total oxygen uptakes of Escherichia coli NCTC 5933 suspensions with glucose and other substrates,Expand
Vaccine constituents
  • In Vaccination, Ch. VII
  • 1988
2 : Types of Antimicrobial Agents
  • Principles and Practice of Disinfcction , Preservation and Sterilization
  • 1992
2: Types of Antimicrobial Agents. In Principles and Practice of Disinfcction, Preservation and Sterilization, 2nd edn
  • 1992
Vaccine constituents . In Vaccination , Ch . VII . British Pharmacopoeia ( 1988 a ) Diphtheria , Tetanus and Pertussis British Pharmacopoeia ( 1988 b ) Thiomersal
  • 1988
Preservative systems compatible with DPTPolio (Salk) and TABTD-Polio (Salk) vaccines
  • British Pharmacopoeia (1988b) Thiomersal,
  • 1974