The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex.

@article{Hehner1999TheAS,
  title={The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex.},
  author={Steffen P. Hehner and Thomas G. Hofmann and Wulf Dr{\"o}ge and Michael Schmitz},
  journal={Journal of immunology},
  year={1999},
  volume={163 10},
  pages={5617-23}
}
The transcription factor NF-kappa B is a key regulator of the cellular inflammatory and immune response. Therefore, components of the NF-kappa B-activating signaling pathways are frequent targets for antiinflammatory agents. This study shows that the sesquiterpene lactone parthenolide inhibits a common step in NF-kappa B activation by preventing the TNF-alpha-induced induction of I kappa B kinase (IKK) and IKK beta, without affecting the activation of p38 and c-Jun N-terminal kinase… CONTINUE READING
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