The antiinflammatory profile of (5H-dibenzo[A, D]-cyclohepten-5-ylidene)acetic acid (WY-41,770), an agent possessing weak prostaglandin synthetase inhibitory activity that is devoid of gastric side effects

@article{Carlson2005TheAP,
  title={The antiinflammatory profile of (5H-dibenzo[A, D]-cyclohepten-5-ylidene)acetic acid (WY-41,770), an agent possessing weak prostaglandin synthetase inhibitory activity that is devoid of gastric side effects},
  author={R. Carlson and L. Datko and J. Chang and S. T. Nielsen and A. Lewis},
  journal={Agents and Actions},
  year={2005},
  volume={14},
  pages={654-661}
}
Wy-41,770 [(5H-dibenzo[a,d]cyclohepten-5-ylidene)acetic acid], a novel acrylic acid, was compared to indomethacin and aspirin in standard antiinflammatory, analgesic and antipyretic animal models. The acute antiinflammatory, analgesic and antipyretic activity of Wy-41,770 (oral ED50s 50–170 mg/kg) was similar to aspirin; however, it was considerably more potent orally in adjuvant arthritis in the rat (ED50, 16 mg/kg) and urate-induced synovitis in the dog (ED50, 4.5 mg/kg). Wy-41,770 was a weak… Expand
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