The antihyperalgesic effect of venlafaxine in diabetic rats does not involve the opioid system

@article{Marchand2003TheAE,
  title={The antihyperalgesic effect of venlafaxine in diabetic rats does not involve the opioid system},
  author={Fabien Marchand and Abdelkrim Alloui and Eric Chapuy and Alejandro Hernandez and Alain Eschalier},
  journal={Neuroscience Letters},
  year={2003},
  volume={342},
  pages={105-108}
}
Venlafaxine (VFX) is a structurally novel antidepressant that inhibits reuptake of serotonin and norepinephrine but, unlike tricyclic antidepressants, has few side effects. The present work studies the antihyperalgesic effect of repeated administrations of VFX (five successive injections of 2.5, 5 or 10 mg/kg, s.c., every half-life) in diabetic rats with the paw pressure test and the effect of the opioid receptor antagonist naloxone (1 mg/kg, i.v.) because an opioidergic mechanism is usually… CONTINUE READING
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