The antiherpesvirus activity and cytotoxicity of sangivamycin.

@article{OBrien1987TheAA,
  title={The antiherpesvirus activity and cytotoxicity of sangivamycin.},
  author={W. O'Brien and J. L. Taylor and T. O'Malley and P. S. Ritch},
  journal={Current eye research},
  year={1987},
  volume={6 1},
  pages={
          255-7
        }
}
  • W. O'Brien, J. L. Taylor, +1 author P. S. Ritch
  • Published 1987
  • Biology, Medicine
  • Current eye research
  • Sangivamycin, 4-amino-5-carboxamido-7-(beta-D-ribofuranosyl)-pyrrolo[2,3-d]-pyrimidine is a structural analog of adenosine belonging to a group of nucleosides classified as pyrrolopyrimidines. Sangivamycin, an adenosine deaminase resistant analog, was found to inhibit the replication of three strains of herpes simplex virus type 1 (HSV-1) by 50% (ED50) at a concentration approximately equal to the concentration which inhibits cell growth by 50% (LD50). Both Vero cells and rabbit corneal stromal… CONTINUE READING
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