The antiherpes drug (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVdU) interferes with formation of N-linked and of O-linked oligosaccharides of the herpes simplex virus type 1 glycoprotein C.

@article{Olofsson1985TheAD,
  title={The antiherpes drug (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVdU) interferes with formation of N-linked and of O-linked oligosaccharides of the herpes simplex virus type 1 glycoprotein C.},
  author={S. Olofsson and M Lundstr{\"o}m and Roelf Datema},
  journal={Virology},
  year={1985},
  volume={147 1},
  pages={
          201-5
        }
}
  • S. Olofsson, M Lundström, Roelf Datema
  • Published 1985
  • Biology, Medicine
  • Virology
  • In HSV-1 infected cell the antiherpes drug (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVdU) exerted at least three different effects on glycosylation of glycoprotein gC. First, an overall decrease of protein glycosylation occurred due to inhibition of synthesis of the lipid-linked oligosaccharides, precursors of N-linked oligosaccharides of gC. Second, an inhibition of processing of N-linked oligosaccharides occurred after the acquisition of endo H-resistance, and possibly due to inhibition of… CONTINUE READING

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