The antigonadotropic action of testosterone but not 7alpha-methyl-19-nortestosterone is attenuated through the 5alpha-reductase pathway in the castrated male rat pituitary gland.

@article{Bandivdekar2000TheAA,
  title={The antigonadotropic action of testosterone but not 7alpha-methyl-19-nortestosterone is attenuated through the 5alpha-reductase pathway in the castrated male rat pituitary gland.},
  author={A. H. Bandivdekar and R. Karp and K. Sundaram and N. Kumar},
  journal={Journal of andrology},
  year={2000},
  volume={21 2},
  pages={
          268-75
        }
}
  • A. H. Bandivdekar, R. Karp, +1 author N. Kumar
  • Published 2000
  • Biology, Medicine
  • Journal of andrology
  • The enzyme 5alpha-reductase plays a significant role in the prostate to amplify the action of testosterone (T) by converting it to a more potent androgen, dihydrotestosterone (DHT). The role of 5alpha-reductase in the testosterone feedback inhibition of gonadotropin secretion from the pituitary has not been elucidated. Therefore, we investigated the role of 5alpha-reductase on T action in in vitro and in vivo models. Castration has been reported to increase the 5alpha-reductase activity in… CONTINUE READING
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