The antigen-presenting activity of fresh, adult parenchymal microglia and perivascular cells from retina.

@article{Gregerson2004TheAA,
  title={The antigen-presenting activity of fresh, adult parenchymal microglia and perivascular cells from retina.},
  author={Dale S Gregerson and Thien N. Sam and Scott W. McPherson},
  journal={Journal of immunology},
  year={2004},
  volume={172 11},
  pages={6587-97}
}
Although several observations show local T cell recognition of retinal Ag, there has been no direct demonstration that the APC were retinal derived, rather than recruited. In this study, CD45(+) cells isolated from immunologically quiescent murine retina were tested in vitro for functional evidence of Ag presentation to naive and Ag-experienced CD4 T cells specific for beta-galactosidase. Because CD45(+) cells from brain have been reported to be efficient APC, they were included for comparison… CONTINUE READING

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