The antifungal protein PAF interferes with PKC/MPK and cAMP/PKA signalling of Aspergillus nidulans

@inproceedings{Binder2010TheAP,
  title={The antifungal protein PAF interferes with PKC/MPK and cAMP/PKA signalling of Aspergillus nidulans},
  author={Ulrike Binder and Christoph Oberparleiter and Vera Meyer and Florentine Marx},
  booktitle={Molecular microbiology},
  year={2010}
}
The Penicillium chrysogenum antifungal protein PAF inhibits polar growth and induces apoptosis in Aspergillus nidulans. We report here that two signalling cascades are implicated in its antifungal activity. PAF activates the cAMP/protein kinase A (Pka) signalling cascade. A pkaA deletion mutant exhibited reduced sensitivity towards PAF. This was substantiated by the use of pharmacological modulators: PAF aggravated the effect of the activator 8-Br-cAMP and partially relieved the repressive… CONTINUE READING