The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway.

@article{Heeg2005TheAE,
  title={The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway.},
  author={Malte H J Heeg and Michael Johann Koziolek and Radovan Vasko and Liliana Schaefer and Kumar Sharma and Gerhard A. M{\"u}ller and Frank Strutz},
  journal={Kidney international},
  year={2005},
  volume={68 1},
  pages={96-109}
}
BACKGROUND The peptide hormone relaxin has been demonstrated to exert antifibrotic effects in renal and extrarenal tissues. The aims of this study were to identify potential anti-fibrotic effects of relaxin on human renal fibroblasts in vitro and to analyze their mechanisms. METHODS All experiments were performed in established renal fibroblast cell lines and in primary cortical fibroblasts. Effects of relaxin were analyzed on cell proliferation, apoptosis, activation of renal fibroblasts… CONTINUE READING

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